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KMID : 0870420160200030110
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Korean Journal of Hepato-Biliary-Pancreatic Surgery
2016 Volume.20 No. 3 p.110 ~ p.115
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Aggressive surgical resection for concomitant liver and lung metastasis in colorectal cancer
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Lee Sung-Hwan
Kim Sung-Hyun
Lim Jin-Hong
Kim Sung-Hoon
Lee Jin-Gu
Kim Dae-Joon
Choi Gi-Hong
Choi Jin-Sub
Kim Kyung-Sik
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Abstract
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Backgrounds/Aims: Aggressive surgical resection for hepatic metastasis is validated, however, concomitant liver and lung metastasis in colorectal cancer patients is equivocal.
Methods: Clinicopathologic data from January 2008 through December 2012 were retrospectively reviewed in 234 patients with colorectal cancer with concomitant liver and lung metastasis. Clinicopathologic factors and survival data were analyzed.
Results: Of the 234 patients, 129 (55.1%) had synchronous concomitant liver and lung metastasis from colorectal cancer and 36 (15.4%) had metachronous metastasis. Surgical resection was performed in 33 patients (25.6%) with synchronous and 6 (16.7%) with metachro-nous metastasis. Surgical resection showed better overall survival in both groups (synchronous, p=0.001; metachro-nous, p=0.028). In the synchronous metastatic group, complete resection of both liver and lung metastatic lesions had better survival outcomes than incomplete resection of two metastatic lesions (p=0.037). The primary site of color-ectal cancer and complete resection were significant prognostic factors (p=0.06 and p=0.003, respectively).
Conclusions: Surgical resection for hepatic and pulmonary metastasis in colorectal cancer can improve complete re-mission and survival rate in resectable cases. Colorectal cancer with concomitant liver and lung metastasis is not a poor prognostic factor or a contraindication for surgical treatments, hence, an aggressive surgical approach may be recommended in well-selected resectable cases.
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KEYWORD
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Colorectal cancer, Liver cancer, Lung cancer, Metastasis
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